Figure 1

Colicins/pyocins and their cognate immunity proteins can be classified into four families based on structural similarity. Structures of different colicin/pyocin–immunity protein complexes (with representative PDB IDs), shown as ribbon diagrams (colored in shades of red and blue, respectively), can be divided into four families based on structure alignment. (A) The E7/Im7-like family: Col-E9–Im9 (1EMV), Col-E2–Im2 (3U43), Col-E7–Im7 (7CEI), Pyo-S2–ImS2 (4QKO), and Pyo-AP41–ImAP41 (4UHP). (B) The Col-D/ImD family (1V74). (C) The Col-E5/Im5 family (2FHZ). (D) The Col-E3/Im3 family (2B5U).