Table 4 Multivariable cox regression analysis of predictors associated with pulmonary tuberculosis treatment success among artisanal miners and relatives.

From: Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community

Treatment success

Variables

Model 1

Model 2

All participants (n = 122)

Non-miners (n = 41)

Miners (n = 81)

aHR (95% CI)

p-value

aHR (95% CI)

p-value

aHR (95% CI)

p-value

Mining-related activities

No

Ref

     

Yes

1.17 (0.84–1.63)

0.35

–

–

–

–

Doubling of TL

1.27 (1.05–1.44)

0.019

1.32 (0.86–1.59)

0.14

1.36 (1.14–1.52)

0.003

Doubling of mtDNA content

1.11 (0.65–1.88)

0.65

1.17 (0.64–2.18)

0.61

1.24 (0.48–3.21)

0.65

  1. Hazard ratios and p-values were computed by Cox regression and expressed for a doubling in TL and mtDNA content at baseline. Model 1 includes all participants. Model 2 stratifies participants by mining related-activities. All models are adjusted for age, sex, tobacco smoking, TB category, years working in artisanal mining (when applicable), HIV-infection status and body mass index. Model 1 also adjusted for Xpert MTB/RIF result.
  2. TL leukocyte telomere length, mtDNA mitochondrial DNA, aHR adjusted hazards ratio, Ref. reference.
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