Table 2 The association between -308G/A polymorphism of TNF-α gene and MS susceptibility.

Group	No. of studies	Case	Control	Pool OR	95% CI	P	I²	P_h	Begg' test	Egger' test
Allele model (A vs. G)
Overall	11	3277	3312	1.47	1.09–1.98	0.013	80.93%	< 0.001	0.061	0.032
Region
Asia	8	1799	1841	1.82	1.31–2.53	< 0.001	81.00%	< 0.001
Europe	3	1696	1796	0.83	0.70–0.99	0.033	18.90%	0.0048
Diagnostic criteria
IDF	4	636	826	1.37	0.90–2.01	0.138	76.30%	0.006
NCEP ATP III	5	2592	2664	1.36	0.85–2.18	0.2	93.50%	< 0.001
CDS	2	167	120	2.39	1.31–4.34	0.004	0.00%	0.546
Dominant model (AA + GA vs GG)
Overall	11	3277	3312	1.77	1.21–2.58	0.003	82.19%	< 0.001	0.161	0.017
Region
Asia	8	1799	1841	2.3	1.64–3.21	< 0.001	67.70%	0.003
Europe	3	1696	1796	0.9	0.69–1.17	0.426	51.80%	0.126
Diagnostic criteria
IDF	4	636	826	1.56	1.03–2.36	0.038	63.40%	0.042
NCEP ATP III	5	2592	2664	1.8	0.95–3.42	0.72	94.30%	< 0.001
CDS	2	167	120	2.23	1.18–4.21	0.014	0.00%	0.561
Recessive model (AA vs GG + GA)
Overall	11	3277	3312	1.08	0.67–1.74	0.744	49.40%	0.032	0.161	0.077
Region
Asia	8	1799	1841	1.52	0.87–2.67	0.14	47.30%	0.066
Europe	3	1696	1796	0.51	0.28–0.92	0.025	0.00%	0.636
Diagnostic criteria
IDF	4	636	826	1.19	0.73–1.95	0.48	22.10%	0.278
NCEP ATP III	5	2592	2664	0.91	0.39–2.11	0.821	63.10%	0.028
CDS	2	167	120	5.5	0.66–45.81	0.115	0.00%	0.028
Homozygous model (AA vs GG)
Overall	11	3277	3312	1.5	0.84–2.70	0.174	61.00%	0.004	0.533	0.169
Region
Asia	8	1799	1841	2.29	1.31–4.01	0.004	37.20%	0.132
Europe	3	1696	1796	0.49	0.27–0.89	0.02	0.00%	0.686
Diagnostic criteria
IDF	4	636	826	1.34	0.81–2.21	0.256	19.70%	0.291
NCEP ATP III	5	2592	2664	1.65	0.48–5.75	0.428	79.50%	0.001
CDS	2	167	120	6.2	0.74–51.78	0.092	0.00%	0.862

IDF the International Diabetes Federation, NCEPATP III the National Cholesterol Education Program Adult Treatment Panel III, CDS Chinese Diabetes Society, OR odds ratio, CI confidence interval.

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