Figure 2
From: Accelerated sonothrombolysis with Definity in a xenographic porcine cerebral thromboembolism model
Representative digital subtraction angiographic images during in vivo procedure. Standard anatomy can be observed in (A). The common carotid artery (CCA) can be seen branching into the ascending pharyngeal artery (APA) and external carotid artery (ECA). The APA ends in the rete mirabile (Rete). The ECA is occluded using bare platinum and hydrogel coils (B), which diverts flow preferentially to the APA and reduces collateral circulation to the brain. The APA is successfully embolized with a human whole blood clot (mTICI < 2b) (C) and treated for 2 h with either sham, rt-PA only, or sonothrombolysis with Definity (2-h rt-PA only treatment arm shown with mTICI ≥ 2b) (D).
