Table 1 31P chemical shift assignments of phosphate in the free oligonucleotides and in the complex with 1a,b. Oligonucleotide “CG” corresponds to duplex d(CGTACG)2 and “AATT” is duplex d(AAGAATTCTT)2.
From: G-quadruplex binding properties of a potent PARP-1 inhibitor derived from 7-azaindole-1-carboxamide
“CG” | δ (ppm) | Δδc | “AATT” | δ (ppm) | Δδc |
|---|---|---|---|---|---|
C1pG2 | − 0.27 | + 0.07 | A1pA2 | broad | n.d |
G2pT3 | − 0.49 | + 0.21 | A2pG3 | − 0.25 | + 0.07 |
T3pA4 | − 0.13 | + 0.26 | G3pA4 | − 0.5d | 0.00 |
A4pC5 | − 0.54 | − 0.07 | A4pA5 | broad | n.d |
C5pG6 | + 0.04 | + 0.24 | A5pT6 | broad | n.d |
− | T6pT7 | − 0.45d | + 0.05 | ||
− | T7pC8 | − 0.38 | + 0.07 | ||
− | C8pT9 | − 0.50d | 0.00 | ||
− | T9pT10 | − 0.38 | 0.00 |
