Figure 3
Longitudinal assessment of brain volume changes with VBM. (a) Three-dimensional representation with positive (blue) and negative (yellow) volume changes observed at 1 week and 12 weeks after baseline (p < 0.05 uncorrected for display purposes). Imaging volumes addressed with 2Pii are labeled with distinct colours (see legend in left panel). Tick spacing is 20 mm on all axes. (b) Statistical maps depicting areas exhibiting significant volume growth or loss (p < 0.05 uncorrected for display purposes, significant at p < 0.05 cluster correction, the blue contour line depicts areas which are significant after TFCE FDR-correction). Color bar indicates t-value. (c) Volume changes of 28 anatomical regions over time assessed by longitudinal VBM between the baseline measurement vs. 1 and 12 weeks in % from baseline. Regions with significant changes from baseline (p < 0.05) are marked (*). Error bars indicate SEM. Abbreviations: Amygdala (Amyg), basal forebrain (bFB), bed nucleus of stria terminalis (BNST), entorhinal cortex (CC_Ent), frontal lobe (CC_frL), occipital lobe 130 164 (CC_ocL), parieto-temporallobe (CC_ptL), colliculus: inferior (Col_inf), colliculus superior (Col_sup), dentate gyrus of hippocampus (DGHC), globus pallidus (GP), hippocampus (HC), hypothalamus (Hyp), interpeduncular nucleus (IPN), lateral septum (la_Sep), mammillary bodies (MaBo), medial septum (med_Sep), midbrain (mid), nucleus accumbens (NAc), olfactory bulbs (olf_bul), olfactory tubercle (olf_tub), periaqueductal gray (PAG), pons (Pons), pontine nucleus (PonNuc), pre-para subiculum (PPSub), striatum (Stri), superior olivary complex (sup_olicomp) and thalamus (Tha).
