Figure 8

Factors found to significantly influence GMV. At 1 week: n = 45 positions from 9 mice; at 12 weeks: n = 35 positions of 7 mice; Linear mixed models. (a) Correlation between the change in fraction of largest nuclei (2250–3000 µm³) within the whole stack and the respective JD p = 0.0001, R² = 0.130, Estimate = − 0.013%. (b) Correlation between relative change in mean nucleus volume within a depth of 350–525 µm and the JD; p = 0.0005, R² = 0.0964, Estimate = − 0.027%. (c) Correlation between nearest neighbour distance changes within a depth of 350–525 µm and the JD. p = 0.002, R² = 0.087, Estimate = 0.030%. (d) Correlation between the change in number of nuclei within a depth of 0–175 µm and the respective JD; p = 0.021, R² = 0.044, Estimate = 0.012%.