Table 2 Basal characteristics of the female subjects with tertiles of FABP4 level at baseline (n = 419).

From: Elevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study

Tertiles of FABP4 level

T1

T2

T3

P

(6.4–18.4 ng/mL)

(18.4–27.3 ng/mL)

(27.4–85.5 ng/mL)

n = 139

n = 140

n = 140

Age (years)

56 ± 15

65 ± 12*

70 ± 10*

< 0.001

Body mass index

21.3 ± 3.1

23.8 ± 3.0*

25.9 ± 4.2*

< 0.001

Waist circumference (cm)

78.2 ± 9.3

85.7 ± 9.4*

92.0 ± 9.4*

< 0.001

Systolic blood pressure (mmHg)

126 ± 25

136 ± 21*

147 ± 27*

< 0.001

Diastolic blood pressure (mmHg)

74 ± 13

77 ± 12

80 ± 13*

0.001

Pulse rate (beats/min)

69 ± 12

72 ± 12

71 ± 9

0.321

Smoking habit

22 (15.8)

10 (7.1)*

9 (6.4)*

0.013

Alcohol drinking habit

85 (61.2)

104 (74.3)*

109 (77.9)*

0.005

Comorbidity

Hypertension

50 (36.0)

79 (56.4)*

94 (67.1)*

< 0.001

Diabetes mellitus

5 (3.6)

11 (7.9)

10 (7.1)

0.288

Dyslipidemia

37 (26.6)

79 (56.4)*

76 (54.3)*

< 0.001

Biochemical data

AST (IU/L)

21 (18–24)

23 (19–27)*

25 (21–30)*

< 0.001

ALT (IU/L)

15 (13–19)

19 (14–24)*

20 (15–26)*

< 0.001

γGTP (IU/L)

16 (13–22)

18 (14–27)

20 (14–28)

0.103

Blood urea nitrogen (mg/dL)

13 ± 4

15 ± 4*

16 ± 4*

< 0.001

Creatinine (mg/dL)

0.5 ± 0.1

0.6 ± 0.1

0.7 ± 0.6*

0.003

eGFR (ml/min/1.73 m2)

91.5 ± 19.5

83.6 ± 15.7*

74.1 ± 19.4*

< 0.001

Uric acid (mg/dL)

4.3 ± 0.9

4.7 ± 0.9*

5.1 ± 1.2*

< 0.001

Total cholesterol (mg/dL)

199 ± 31

212 ± 31*

212 ± 35*

0.001

LDL cholesterol (mg/dL)

116 ± 28

127 ± 32*

129 ± 32*

0.001

HDL cholesterol (mg/dL)

67 ± 15

63 ± 17*

61 ± 16*

0.002

Triglycerides (mg/dL)

71 (56–100)

95 (67–122)*

94 (74–136)*

< 0.001

Fasting glucose (mg/dL)

92 ± 11

98 ± 19*

100 ± 22*

0.001

Insulin (µU/ml)

4.1 (3.0–5.5)

4.9 (3.7–7.0)*

5.9 (4.1–8.7)*

< 0.001

HOMA-R

0.90 (0.67–1.22)

1.16 (0.80–1.78)*

1.37 (0.94–2.29)*

< 0.001

Hemoglobin A1c (%)

4.9 ± 0.4

5.2 ± 0.6*

5.3 ± 0.7*

< 0.001

BNP (pg/mL)

17 (11–23)

19 (11–37)*

23 (14–40)*

0.003

hsCRP (mg/dL)

0.02 (0.01–0.05)

0.04 (0.02–0.08)

0.05 (0.03–0.10)*

< 0.001

  1. Variables are expressed as number (%), means ± SD or medians (interquartile ranges).
  2. AST aspartate transaminase, ALT alanine transaminase, BNP brain natriuretic peptide, eGFR estimated glomerular filtration rate, FABP4 fatty acid-binding protein 4, γGTP γ-glutamyl transpeptidase, HDL high-density lipoprotein, HOMA-R homeostasis model assessment of insulin resistance, hsCRP high-sensitivity C-reactive protein, LDL low-density lipoprotein.
  3. *P < 0.05 versus T1.
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