Figure 8 | Scientific Reports

Figure 8

From: Chemosensitizing activity of peptide from Lentinus squarrosulus (Mont.) on cisplatin-induced apoptosis in human lung cancer cells

Figure 8

Proposed regulatory machinery of chemosensitizing effect of peptide extracted from Lentinus squarrosulus on cisplatin-induced apoptosis in human lung cancer cells. The peptide enhances the suppressive activity of cisplatin on integrin-mediating survival which resultes in the downregulation of integrin and down-stream signaling proteins including p-FAK/FAK, p-Src/Src and p-Akt/Akt as well as activation of apoptosis mediated by overexpression of p53 which correlates with increased Bax and diminution of anti-apoptosis Mcl-1 and Bcl-2 proteins. The effects of the peptide and cisplatin at non-toxic concentrations is indicated by red and blue small arrows, respectively. Big pink arrows represent the augmented cytotoxicity of cisplatin after pretreatment of human lung cancer cells with 0.4 M NaCl fraction of L. squarrosulus peptides.

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