Figure 3

Phylogenomic tree inferred by maximum-likelihood method from SNP-based core genomes alignment of the S. aureus strains. The multiple genome sequence alignments of 11 global S. aureus strains were generated by the online tool REALPHY using S. aureus NCTC 8325 as the reference genome. An unrooted phylogenomic tree was inferred by approximately Maximum Likelihood method using Generalized Time-Reversible (GTR) model with gamma distribution of rates and 100 bootstrap replicates. Bootstrap support value is indicated as a percentage at each node. The roman numerals denote the arbitrary clusters of strains. The ST22 reference genome HO 5096 0412 (NC_017763) resembles a phylogenetic outgroup.