Table 3 Machine learning selected genes: Reactome and KEGG pathways involved. The pathways that could be related to squamous cell carcinoma of the lung are shown in Reactome column. Most of the genes do not have a pathway related to KEGG database, they are labeled as null. If there were more than three pathways available in either database just three pathways or less were selected when its biological function could be useful in cancer progression, growth, or maintenance. If just one pathway was available, it was written in the corresponding field. Null is used when no hits were found in the database. Only. genes that do not appear in either database were not presented.
From: Novel gene signatures for stage classification of the squamous cell carcinoma of the lung
Name | Reactome | KEGG |
|---|---|---|
ARPC5 | EPH-Ephrin signaling | Tight junction, Regulation of actin cytoskeleton, Bacterial invasion of epithelial cells |
ABCA1 | Regulation of lipid metabolism by PPARalpha | ABC transporters |
HORMAD2 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends Nonhomologous End-Joining (NHEJ) | Null |
C3orf52 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Complex I biogenesis | Null |
TMTC3 | Reelin signalling pathway | Null |
MUC4 | O-linked glycosylation | Null |
CALM1 | Beta-catenin independent WNT signaling RAS processing RAF/MAP kinase cascade Signaling downstream of RAS mutant Signaling by RAF1 mutants | Null |
PRG2 | Neutrophil degranulation | Asthma |
