Figure 8 | Scientific Reports

Figure 8

From: Mechanical stretch induces Ca2+ influx and extracellular release of PGE2 through Piezo1 activation in trabecular meshwork cells

Figure 8

Proposed model of how Piezo1 activation contributes IOP regulation in human trabecular meshwork cells. Membrane stretch activates Piezo1 on hTM cells, causing Ca2+ influx. This increase in intracellular Ca2+ activates cytosolic phospholipase A2 (cPLA2) and releases arachidonic acid (AA) from membrane phospholipids. The liberated arachidonic acid is metabolized to produce PGE2, which causes cell relaxation via EP receptor, leading to a decrease in IOP.

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