Figure 5

Intersection analysis and protein–protein interaction network with PXR. (A) Gene set 1 was constructed by the intersection between the active genes in high expression group after GSEA and the genes in module that are negatively correlated with disease after WGCNA. (B) Gene set 2 was constructed by the intersection between the active genes in low expression group after GSEA and the genes in module that are positively correlated with disease after WGCNA. (C) PPI-network of 94 overlapping gene in gene set 1. (D) PPI-network of 41 overlapping gene in gene set 2. (E) CES2, ABCG2, PCK1, PPARGC1A and CYP2B6 from gene set 1 and CXCL8 from gene set 2 were predicted to interact and functionally associate with PXR.