Figure 1 | Scientific Reports

Figure 1

From: Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology

Figure 1

Hierarchical clustering of samples. A heatmap shows the clustering of the 20 Alzheimer’s disease (AD) and neurologically normal control (control) brain tissue samples based on their differential gene (transcript) expression (z-values). Samples are from the primary visual cortex (VIC) and precuneus (PREC); regions that are mildly- and moderately affected by tau pathology respectively in the AD brain at post-mortem. The colour scale shows transcripts that are upregulated (red) or downregulated (blue) relative to mean expression of all samples. Four control samples (PREC and VIC regions from IS43 and IS44) cluster with the cases.

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