Table 8 Quantification of AD neuropathology in the RNA-Seq cohort.
Mean (S.D.) | AD (n = 26) | Control (n = 22) | p value |
|---|---|---|---|
PREC—AT8-tau + ve neuron density (mm2) | 20 (14) | 0 | < 0.0001 |
PREC—areal Aβ fraction | 0.07 (0.05) | 0.008 (0.008) | < 0.0001 |
PREC—neuronal density (mm2) | 276 (56) | 283 (63) | 0.7 |
VIC—AT8-tau + ve neuron density (mm2) | 8 (9) | 0 | 0.0003 |
VIC—areal Aβ fraction | 0.07 (0.05) | 0.002 (0.007) | < 0.0001 |
VIC—neuronal density (mm2) | 309 (41) | 278 (62) | 0.06 |
PREC—RIN | 4.1 (0.9) | 5.2 (1.0) | 0.0001 |
VIC—RIN | 4.2 (0.9) | 5.1 (1.2) | 0.003 |
PREC | VIC | p value | |
|---|---|---|---|
Inter-regional comparisons (cases only) | |||
Areal Aβ fraction | 0.07 (0.05) | 0.07 (0.05) | 0.8 |
AT8-tau + ve neuron density | 20 (14) | 8 (9) | 0.0009 |
