Table 1 Summary of the main characteristics of the included studies.
References | Species, gender | Age or Weight | DOX Cumulative Dose, route | Timing | Modality | Duration in weeks (sessions) | Training Protocol | Final ECO |
|---|---|---|---|---|---|---|---|---|
Dolinsky et al., 201317 | Mice (C57BL/6), F | 10 weeks | 32 mg/kg, IP | During and after DOX | AET—Treadmill | 8 (40) | Acclimation: 5 days at 10 m/min for 30 min/day. Progressive treadmill during the morning to 18 m/min at 0% grade for 45 min 5 days/week | 1 day |
Hallet al., 201918 | Rats (Sprague–Dawley), F | 175–200 g | 15 mg/kg, IP | Before DOX | AET—Wheel | 16 | Acclimation: 1 week. Free access, voluntary, 24 h/day | 5 days |
Hayard et al., 201119 | Rats (Sprague–Dawley), M | 25 days | 14 mg/kg, IP | During DOX | AET—Wheel | 10 | Free access, voluntary, 24 h/day | 1 day |
Hydock et al., 200820 | Rats (Sprague–Dawley), M | 250–350 g | 10 mg/kg, IP | Before DOX | AET—Treadmill or Wheel | 10 (50) | Acclimation: 5 days at 13 m/min for 10–15 min. TM: progressive treadmill to 20–30 m/min, 20–60 min, 0–18º grade for 5 days/week. WR: housed 1 per cage with free access to voluntary wheel 24 h/day | 5 to 10 days |
Hydock et al., 201121 | Rats (Sprague–Dawley), M | 250 g | 10 mg/kg, IP | Before DOX | AET—Treadmill or Wheel | 10 (50) | TM: progressive (20–30 m/min to 20–60 min) at 0-18º grade for 5 days/week WR: Free access, voluntary, 24 h/day | 4 weeks |
Hydock et al., 201222 | Rats (Sprague–Dawley), F | 200 g | 15 or 20 mg/kg, IP | During DOX | AET—Wheel | 10 | Free access, voluntary, 24 h/day | 10 weeks |
Jensen et al., 201323 | Rats (Sprague–Dawley), F | 10–11 weeks | 10 mg/kg, IP | Before DOX | AET—Treadmill or Wheel | 10 (50) | TM: 5 days/week at 13 m/min up to a 5% grade for 20 min/day gradually increasing throughout weeks 1–4 and 30 m/min up to a 18% grade for 60 min during weeks 5–10. WR: Free access, voluntary, 24 h/day | 1 to 9 days |
Lien et al., 201524 | Rats (Sprague–Dawley), M | 10 weeks | 10 or 15 mg/kg, IP | Before DOX | AET—Treadmill or Wheel | 0.71 (5) | TM: progressive during the dark cycle to 20–60 min/day for 5 days, 18–24 m/min, 0% grade. WR: Free access, voluntary, 24 h/day | 5 days |
Matsuura et al., 201025 | Rats (Sprague–Dawley), M | 12 weeks | 10 mg/kg, IP | After DOX | AET—Treadmill | 6 (30) | Progressive with velocity increased 50% to 60% of maximal velocity with 0% grade for 5 days/week, 60 min/day | - |
Morton et al., 201826 | Rats (Sprague–Dawley), F | 6 months | 20 mg/kg, IP | Before DOX | AET—Treadmill | 1.42 (10) | Acclimation: 5 consecutive days (10, 20, 30, 40 and 50 min/day on days 1–5, respectively). Two days of rest. 60 min/day at 30 m/min, 0% grade (estimated work rate of 70% VO2máx) with two days of rest after day 5 of training | 2 days |
Parry et al., 201527 | Rats (Fischer 344), F | 11 weeks | 12 mg/kg, IP | Before DOX | AET—Wheel | 11 | Free access, voluntary, 24 h/day, 7 days/week | 1 to 5 days |
Pfannenstiel et al., 201828 | Rats (Sprague–Dawley), M | 10 weeks | 12.5 mg/kg, IP | Before DOX | Elevation of food and water | 12 | Cages allowing for a progressive elevation (from 20.32 to 28 cm) of food and water. Cage height remained at 28 cm for one week. Next, the height was raised by 2.5 cm, and incremental 2.5 cm occurred every 3 days until 35.5 cm, which continued for additional 10 weeks | 5 days |
Sturgeon et al., 201429 | Mice (C57BL/6), M | 6–8 weeks | 4 mg/kg, IP | During DOX | AET—Treadmill | 2 (10) | 10 m/min for 45 min, 5 days/week | 2 days |
Wang et al., 201830 | Mice (C57BL/6 J, U; Athymic Swiss Nude, M), | 4 weeks | 10 mg/kg, IP | During DOX | AET—Treadmill | 2 (10) | 12 m/min, 0% grade, 5 days/week with 2 consecutive days of rest | 1 day |
