Figure 1
Alignment of human APP and Tau network from Amyloid Interactome and homologous C. elegans network by MAGNA++ with combination of biological and topological information, containing both correct and incorrect alignments. The human network (top) and the C. elegans network (bottom) are displayed with the layout of nodes corresponding to the predicted ortholog mapping. Human proteins with no predicted orthologs in the C. elegans network are isolated on the upper side of the human network. Two dotted black lines show the positioning of ortholog pairs APP & APL-1 and Tau & PTL-1 that were not correctly aligned; APP and Tau were not mapped to any C. elegans protein, while APL-1 and PTL-1 were aligned with RNF32 and PRAM1, respectively. All node alignments are available in Supplementary Table 3. Groups of nodes surrounded by dotted lines represent proteins mapped to the same predicted ortholog. These protein nodes have been colored accordingly, to make it easier to detect. Detailed information about the proteins in these networks can be retrieved via the web application (http://thalis.biol.uoa.gr/celegans_human_AD/).
