Figure 3 | Scientific Reports

Figure 3

From: Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach

Figure 3

Conservation of the APP processing pathway in H. sapiens and C. elegans. Shown here are elements of the APP processing pathway found in the Common Network, extended with relevant proteins and interactions from the “Top 100 interaction partners” dataset. Elements associated with α- and γ-secretase activity are conserved in both organisms, while β-secretase is missing from C. elegans. Even though all interactions that take place in this pathway have been experimentally investigated in human, information related to AD could be retrieved only for two C. elegans interactions.

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