Figure 8
Top 34 gene mutations in TCGA TNBC cases. (Top left and right) Mutational analysis of the TNBC cases in TCGA identifies TP53 (61.4%), TTN (28.3%), MUC4 (18.9%), MT-CYB (12.6%), SPTA1 (11%), and USH2A (10.2%) as the most frequently mutated genes. (Bottom left) Median and mean mutation count are 77 and 112.1, respectively. (Bottom right) Mutation frequencies of several genes in TNBC as determined by this study (TCGA) or other whole genome or exome sequencing studies (Ref 1 =37, Ref 2 =38). (Top left and right, Bottom left) Images generated with R 4.0.2 (https://www.R-project.org)35. (Bottom right) Image generated with Adobe Photoshop CC 2018 (https://www.adobe.com).
