Table 3 Percentage of longitudinal changes in DTI metrics, linear regression slopes and significance of slopes of each significant cluster.

From: Signatures of white-matter microstructure degradation during aging and its association with cognitive status

Metric

M2–M1 (%)

Slope

Test statistic

FA cluster 1

− 4.35

− 0.020

F(1,100) = 7.62, p = 0.007**

FA cluster 2

− 3.94

− 0.016

F(1,100) = 8.42, p = 0.005**

AD cluster 1

3.30

0.00004

F(1,100) = 20.51, p < 0.0001***

RD cluster 1

5.45

0.00004

F(1,100) = 1.74, p = 0.19

RD cluster 2

4.78

0.00003

F(1,100) = 9.09, p = 0.003**

MD cluster 1

3.69

0.00003

F(1,100) = 11.96, p = 0.0008***

  1. FA fractional anisotropy, AD axial diffusivity, MD mean diffusivity, RD radial diffusivity, M1 timepoint 1, M2 timepoint 2.
  2. Significance codes: *p < 0.05, **p < 0.01, ***p < 0.001.
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