Table 1 Clinical characteristics of ACPA-positive individuals with arthralgia at risk of RA and healthy controls (Phase I).

From: High miR-451 expression in peripheral blood mononuclear cells from subjects at risk of developing rheumatoid arthritis

Variable

RA-risk individuals

HC

p Value

n

19

19

–

Gender, female/male

13/6

12/7

NS

Age, years

39.72 [33.16–48.13]

43.00 [31.92–58.88]

NS

CRP, mg/l

2.70 [0.87–6.93]

1.42 [0.54–2.20]

0.05

ESR, mm/h

11.00 [6.00–19.00]

*

–

VAS, mm

10.00 [0.00–50.00]

NA

–

TJC, n

0.00 [0.00–1.00]

NA

–

RF positivity, n (%)

12 (63%)

0 (0%)

< 0.001

ACPA positivity, n (%)

19 (100%)

0 (0%)

< 0.001

Anti-CCP, U/ml

91.00 [34.70–800.00]

15.13 [13.42–17.30]

0.002

Anti-MCV, U/ml

41.40 [20.90–199.50]

8.20 [5.9–9.80]

< 0.001

  1. Abbreviations: ACPA, anti-citrullinated protein antibodies (positive for at least one of the following antibodies: anti-CCP or anti-MCV); CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; HC, healthy controls; NA, not applicable; NS, not significant; RF, rheumatoid factor (positivity of at least one of the following: IgG, IgA, or IgM RF assessed using an ELISA); TJC, 68 tender joint count; VAS, visual analogue scale (patient’s global health assessment). Data are presented as medians and interquartile ranges [IQRs]. *Missing data.
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