Figure 5 | Scientific Reports

Figure 5

From: Notch signaling drives development of Barrett’s metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa

Figure 5

Notch activation in Dclk1-positive crypt epithelial cells induces upregulation of oncogenic signaling. (A) Analysis of HALLMARK gene sets (OneVsRest) of the indicated genotypes, scale bar indicates log2-fold changes of genes (Z-Scores; positive lgFC indicates higher gene expression in the respective group). (B) Grouped analyses of the indicated genotypes for changes in hallmark pathway gene sets, NES = normalized enrichment score, FDR = false discovery rate (red indicating increased, blue indicating decreased).

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