Figure 5 | Scientific Reports

Figure 5

From: Using the Microwell-mesh to culture microtissues in vitro and as a carrier to implant microtissues in vivo into mice

Figure 5

Microtumour establishment rates and histological comparison to original PDX. (a) Rates of microtumour establishment with different PDX-derived PCa cell populations using the Microwell-mesh platform. Immunohistochemistry staining of tissues derived from microtumours for human cell-specific Ku70 and PSA. Scale bars = 50 µm. (b) Representative images of parental PDX tumours and the tissues harvested following PDX re-establishment in mice using the Microwell-mesh platform, after 8 weeks in vivo. (c) The number of tumours recovered from transplanted microtumours showing “No growth”, “Medium growth”, and “High growth” are shown in pie charts for each PDX population, as well as 3 representative photographic images.

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