Table 1 Demographic, clinical, and evoked pain data by group for episodic migraine patients and healthy individuals.

From: Slowly repeated evoked pain (SREP) as a central sensitization marker in episodic migraine patients

Variables

EM (n = 40)

Healthy (n = 40)

EM vs Healthy

t or χ2

p**

η2

Age (years)

20.95 ± 3.05

21.25 ± 3.45

− 0.412

0.682

0.002

BMI

23.04 ± 3.52

22.09 ± 3.36

1.244

0.217

0.019

Pain threshold (kg)

3.38 ± 1.45

3.18 ± 1.76

0.553

0.582

0.004

Pain tolerance (kg)

7.99 ± 1.92

7.99 ± 2.19

0.004

0.997

< 0.001

SREP sensitization (VAS) [0–10]

1.00 ± 0.62

− 15 ± 0.98

5.544

< 0.001***

0.283

SREP stimulus pressure (kg)*

4.82 ± 1.36

4.68 ± 1.76

0.391

0.697

0.002

TSP (NRS) [0–10]

0.43 ± 0.72

0.56 ± 1.12

− 0.654

0.515

0.005

Present Pain Index (MPQ) [0–5]

0.45 ± 0.86

0.35 ± 0.58

0.602

0.549

0.005

First pain rating SREP (VAS) [0–10]

3.25 ± 1.86

3.47 ± 1.94

− 0.518

0.606

0.003

First pain rating TSP (NRS) [0–10]

1.44 ± 1.29

1.31 ± 1.34

0.424

0.673

0.002

Catastrophizing (CSQ) [0–36]

15.28 ± 7.37

7.23 ± 5.58

5.509

< 0.001***

0.280

Anxiety (HADS-A) [0–21]

8.30 ± 2.95

8.18 ± 3.10

0.185

0.854

< 0.001

Depression (HADS-D) [0–21]

3.78 ± 3.00

4.38 ± 3.46

− 0.828

0.410

0.009

Regular analgesics use, N (%)

24 [60%]

0 [0%]

34.286

< 0.001***

0.002

Age of onset of migraine (years)

11.98 ± 3.62

Intensity of migraine attacks [0–10]

7.68 ± 1.00

Duration of migraine attacks (h)

10.15 ± 6.10

Frequency of migraine (days/month)

6.68 ± 3.74

  1. Means ± Standard Deviations, and results of the group comparisons (t or χ2, p, and η2).
  2. *Individually calibrated stimulus pressure for the SREP procedure in kg/cm2.
  3. **Original p-values from group comparisons.
  4. ***Significant p-values after Bonferroni adjustment remained below 0.001.
  5. BMI Body Mass Index, CSQ Coping Strategies Questionnaire, EM Episodic Migraine, HADS Hospital Anxiety and Depression Scale, MPQ McGill Pain Questionnaire, NRS Numeric Rating Scale, SREP Slowly Repeated Evoked Pain, TSP Temporal Summation of Pain, VAS Visual Analogic Scale.