Figure 5
Hepatic pFUS attenuates circulating ALT, reduces gross liver weight, and diminishes proinflammatory cytokines levels. (A) pFUS attenuates ALT increase seen in Western diet–sham mice (WD–sham, week 9 vs week 16, ** P < 0.01, two-way ANOVA). pFUS treatment reduces endpoint ALT levels (* P < 0.05, two-way ANOVA). (B) Hepatic pFUS reduces liver weight. Western diet–sham mice had significantly increased liver weight compared to control diet–sham mice (*** P < 0.001, one-way ANOVA). Western diet–pFUS mice had significantly lower liver weight compared to Western diet–sham mice (*** P < 0.001, one-way ANOVA). (C,D) Hepatic pFUS lowers proinflammatory cytokines in the liver. Wester diet–sham mice had increased TNF levels compared to control diet–sham mice (C, *** P < 0.001, one-way ANOVA). Hepatic pFUS lowered TNF levels in Western diet-fed mice (C, *** P < 0.001, one-way ANOVA). Western diet–sham mice had increased IL-1β levels compared to control diet–sham mice (D, ** P < 0.01, one-way ANOVA). Hepatic pFUS stimulated Western diet-fed animals had lower IL-1β levels (D, * P < 0.05, one-way ANOVA).
