Table 1 Biological Pathways Significantly Altered during FDMI. GSEA reveals 1 Reactome pathway significantly suppressed after prolonged occluder wear. ES, enrichment score; NES, normalised enrichment score; FDR, false discovery rate.

From: RNA-seq and GSEA identifies suppression of ligand-gated chloride efflux channels as the major gene pathway contributing to form deprivation myopia

Pathway

Database

Total # Genes Measured

# Genes contributing to ES

Leading edge subset genes

ES

NES

FDR

Ligand-gated Ion Channel Transport

Reactome

16

9

GABRR2, GABRA6, GABRG2, GLRA3, GABRA2, GLRA2, GABRA5, GABRA1, GABRG3

− 0.68

− 1.96

.19

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