Figure 3
Examples of HIVM tumor observations for patients who had partial response (A), stable disease (B), and progressive disease (C) by standard RECIST criteria. The left side panels depict baseline imaging (CT scan or MRI) prior to neoadjuvant therapy. The middle panels depict follow-up imaging after neoadjuvant therapy just prior to undergoing CRS-HIPEC. Yellow arrows highlight the areas of disease. The right side panels depict HIVM PC-associated vessel observations. Patients who had achieved partial response had the highest density of functional vessels, lowest density of non-functional vessels, and the lowest proportion of non-function vessels when compared to patients who had stable disease or progressive disease. Although the subset analysis of patients who had neoadjuvant therapy did not show significant associations between RECIST response and tumor HIVM vessel characteristics, these individual patient observations provide early evidence that there may be a correlation between tumor response and tumor-associated vessels.
