Table 2 Characteristics of RA patients by Frailty status.
Frailty score (SOF index) | Robust | Prefrail | Frail | P value |
|---|---|---|---|---|
0 | 1 | 2 or 3 | ||
(N = 306) | n = 135 (44.1%) | n = 100 (32.7%) | n = 71 (23.2%) | |
Age, year | 62.0 (49.0–69.0) | 64.0 (57.0–71.0) | 67.0 (59.0–74.0) | 0.0012 |
Body mass index, kg/m2 | 21.2 (19.5–23.8) | 21.7 (19.2–24.8) | 20.7 (18.8–22.9) | 0.26 |
Factors associated with frailty | ||||
Skeletal mass index, kg/m2 | 5.87 (5.35–6.32) | 5.69 (5.16–6.27) | 5.35 (4.88–5.94) | 0.0054 |
Right hand grip, kg | 18.1 (12.9–24.2) | 15.7 (9.7–20.6) | 10.0 (6.4–14.7) | < 0.0001 |
Light hand grip, kg | 17.8 (11.9–22.9) | 15.1 (9.6–20.6) | 9.0 (5.5–14.8) | < 0.0001 |
Walking speed, m/s | 1.12 (0.98–1.25) | 1.05 (0.81–1.17) | 0.73 (0.62–0.96) | < 0.0001 |
Any fall in previous year, n (%) | 23 (17.0) | 16 (16.0) | 21 (29.6) | 0.058 |
Any fracture in previous year, n (%) | 0 (0) | 9 (9) | 9 (12.7) | 0.0181 |
Laboratory data | ||||
Hemoglobin, g/dL | 12.9 (12.0–13.5) | 12.6 (11.8–13.2) | 12.1 (11.2–13.0) | 0.0023 |
Albumin, g/dL | 4.0 (3.8–4.2) | 3.9 (3.7–4.1) | 3.9 (3.6–4.1) | 0.0139 |
CRP, mg/dL | 0.1 (0–0.2) | 0.1 (0–0.3) | 0.1 (0–0.4) | 0.037 |
RA disease characteristics | d | |||
Disease duration, year | 7.0 (3.0–20) | 8.0 (3.0–19.8) | 15.0 (7–27) | 0.0019 |
DAS28-ESR | 2.32 (1.84–3.15) | 2.78 (2.08–3.68) | 3.38 (2.78–4.23) | < 0.0001 |
HAQ | 0.13 (0–0.50) | 0.63 (0.25–1.13) | 1.25 (0.75–1.63) | < 0.0001 |
Stage | 1 (1–2) | 2 (2–2) | 2 (2–2) | 0.026 |
Class | 3 (2–4) | 3 (2–4) | 3 (2–4) | < 0.0001 |
Current therapeutic agent | ||||
MTX use, n (%) | 109 (80.7) | 70 (70.0) | 43 (60.6) | 0.0016 |
Biological agent use, n (%) | 61 (45.2) | 47 (47.0) | 26 (36.6) | 0.31 |
Prednisolone use, n (%) | 28 (20.7) | 30 (30.0) | 30 (42.2) | 0.0012 |
