Figure 4

Correlation between exosomal DE-miRNAs and anxiety and depression in SUDs. (A–H) Correlation between exosomal DE-miRNAs and anxiety in SUDs. (A,E) correlation between hsa-miR-16-5p and HAM-A scores in HDPs and MDPs, respectively; (B,F) correlation between hsa-miR-129-5p and HAM-A scores in HDPs and MDPs, respectively; (C,G) correlation between hsa-miR-363-3p and HAM-A scores in HDPs and MDPs, respectively; (D,H) correlation between hsa-miR-92a-3p and HAM-A scores in HDPs and MDPs, respectively. (I–P) Correlation between exosomal DE-miRNAs and anxiety in SUDs. (I,M) correlation between hsa-miR-16-5p and HAM-D scores in HDPs and MDPs, respectively; (J,N) correlation between hsa-miR-129-5p and HAM-D scores in HDPs and MDPs, respectively; (K,O) correlation between miR-363-3p and HAMD in HDPs and MDPs, respectively; (L,P) correlation between miR-92a-3p and HAMD in HDPs and MDPs, respectively. The number on X-axis stands for reads calculated by TPM, the number on Y-axis stands for scores of HAM-A/HAM-D. MDPs Exosomes obtained from methamphetamine-dependent patients, HDPs Exosomes obtained from heroin-dependent patients, HCs Exosomes obtained from healthy controls, SUDs substance use disorders, HAM-A Hamilton Anxiety Rating Scale, HAM-D Hamilton Depression Rating Scale, TPM transcript per million.