Table 2 Diagnosis distribution of LCCG cohort including subgroups with corresponding germline mutations.
Group # | Diagnosis | nA | Diagnosis Subgroup | nB | nMutC | Germline Mutations |
|---|---|---|---|---|---|---|
1 | Leukemia | 262 | ALL | 219 | 2 | BRCA2, TP53 |
AML | 37 | 2 | PMS2, PALB2 | |||
Other | 6 | 0 | na | |||
2 | CNS_tumor | 149 | Astrocytoma | 61 | 4 | 2 × BRCA2, PMS2, NF1 |
Ependyoma | 14 | 0 | na | |||
Medulloblastoma | 25 | 0 | na | |||
Ganglioma | 6 | 0 | na | |||
Craniopharyngioma | 6 | 0 | na | |||
Opticusglioma | 9 | 3 | 3 × NF1 | |||
Other_Brain_tumor | 28 | 1 | NF1 | |||
3 & 9 | Lymphoma | 133 | NHL | 56 | 2 | APC, BRCA1 |
Hodgkin's_lymphoma | 58 | 0 | na | |||
Histiocytosis | 19 | 0 | na | |||
4 | Wilms'_tumor | 59 | Wilms'_tumor | 59 | 2 | BRCA2, SDHA |
5 | Soft-tissue_Sarcoma | 56 | Non-rhabdomyosarcoma | 16 | 1 | TP53 |
Rhabdomyosarcoma_Embryonal | 30 | 1 | TP53 | |||
Rhabdomyosarcoma_Alveolar | 7 | 0 | na | |||
Rhabdomyosarcoma_Unspecified | 3 | 1 | NF1 | |||
6 | Neuroblastoma | 36 | Neuroblastoma | 36 | 3 | BRCA1, PTCH1, NF1 |
7 | Germ-cell_tumor | 14 | Germ-cell_tumor | 14 | 0 | na |
8 | Bone_tumor | 58 | Osteosarcoma | 22 | 2 | 2 × TP53 |
Ewing_sarcoma | 36 | 0 | na | |||
10 | Retinoblastoma | 5 | Retinoblastoma | 5 | 3 | 3 × RB1 |
11 | Carcinoma | 6 | ACT | 1 | 1 | TP53 |
Other Carcinoma | 5 | 0 | na | |||
12 | Hepatic_tumor | 9 | Hepatoblastoma | 9 | 1 | SDHA |
13 | Other | 3 | Other | 3 | 1 | NF1 |
