Figure 6
From: Pharmacological inhibition of tumor anabolism and host catabolism as a cancer therapy
The 6 drugs scheme reverts the low glucose peak seen in non-treated, tumor-bearing mice, and prevents the loss of subcutaneous fat mass. (a) Delta of blood glucose at days 0 and 21 of treatment, and the area under the curve per condition. (b) mRNA relative expression of CITED1, TBX1, PPARγ, and UCP1. (c) H&E staining of subcutaneous fat samples isolated after 21 days of treatment. H&E Images are presented at 10X magnification. The images are representative of the data obtained. Data are expressed as means ± s.e.m. N = 1 independent experiment, 10 mice/group. Statistical analyses were performed with one-way ANOVA with Dunnet correction. Scale bars = 200 μm. 6 drugs: Orlistat + lonidamine + DON + growth hormone + insulin + indomethacin; AUC: Area under the curve; ns: non-significant; *p < 0.05; **p < 0.01; ****p < 0.0001.
