Table 1 Total N-glycan coverage of the residues involved in each binding mode. Data are calculated from systems G1–4 in Table 2. The contributions of each residue to each binding mode are extracted from our previous work14. The results indicate how much of the CD44-HABD surface (that is critical to hyaluronate binding) is covered by N-glycans.
From: N-Glycosylation can selectively block or foster different receptor–ligand binding modes
Binding mode | Realistic asialo coverage (%) | Realistic monosialo coverage (%) | Partial monosialo coverage (%) | Pentasacharides coverage (%) |
|---|---|---|---|---|
Cryst. | \(\text {50} \pm \text {13}\) | \(\text {51} \pm \text {8}\) | \(\text {35} \pm \text {18}\) | \(\text {32} \pm \text {7}\) |
Parallel | \(\text {48} \pm \text {14}\) | \(\text {46} \pm \text {11}\) | \(\text {34} \pm \text {17}\) | \(\text {26} \pm \text {6}\) |
Upright | \(\text {29} \pm \text {12}\) | \(\text {30} \pm \text {7}\) | \(\text {21} \pm \text {13}\) | \(\text {16} \pm \text {4}\) |
