Figure 1

Confirmation of plaques identity in micro CT data: (a) Composed picture of the micro CT scan sections from control (left side) and transgenic (right side) rat brain. The transgenic tissue exhibits a large amount of suspect amyloid plaques (right part of the brain). Selected detail image of corresponding areas that are shown in pink and blue frames. Basic anatomical structures visualized in micro CT scan: CA1 and CA3 cornu Ammonis 1 and 3 of hippocampus, CC corpus callosum, CP caudoputamen, DG dentate gyrus, FX fornix, INT internal capsule, LV lateral ventricle, MTT mamillothalamic tract, OPN olivary pretectal nucleus, V3 third ventricle. Micro CT image (b) and immunohistology section with detected plaques (c) of corresponding coronal brain sections from the transgenic rat no. 60 confirms the presence of plaques in micro CT scan. Selected plaques are indicated by white arrows in enlarged slice windows (d)41.