Table 1 Summary of microglia characteristics in RT + aPD-1 treated mice and controls.

From: Neuroinflammatory changes of the normal brain tissue in cured mice following combined radiation and anti-PD-1 blockade therapy for glioma

Measure

Sham saline (mean ± SEM)

RT + aPD-1 (mean ± SEM)

t-statistic

P value

Significance

Soma surface area (µm2)

180.76 ± 19.73

212.29 ± 20.73

1.101

0.286963

NS

Number of primary branches

3.38 ± 0.38

3.54 ± 0.31

0.335

0.742064

NS

Number of secondary branches

6.00 ± 0.93

4.31 ± 0.67

1.478

0.161516

NS

Branch endpoints

13.00 ± 1.45

6.85 ± 0.78

3.739

0.003852

**

Total branch length (µm)

244.39 ± 28.43

176.57 ± 22.71

1.863

0.085135

NS

  1. The first column lists the measures of characteristics evaluated and the measurement units in parenthesis, when applicable. The second the third columns list the mean ± SEM for each measurement from the control group (sham saline) and RT + aPD-1 treated mice, respectively. The fourth column lists the t statistic for each measurement. The last column indicates the corresponding P value for Student’s t test. Microglia from RT + aPD-1 treated mice had fewer branch endpoints compared to the controls. Microglia characteristics were similar with regards to soma surface area, number of primary branches, number of secondary branches, and total branch length between the two groups.
  2. **P < 0.01.
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