Figure 2 | Scientific Reports

Figure 2

From: Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response

Figure 2

Response Similarity Analysis of NSCLC cell lines from the TMES and xenografts relative to 2D static cultures. (A–C) Xenograft vs TMES scatterplots log2 fold changes relative to static cell culture. Points are colored by their response similarity (RSI), where darker, more saturated colors indicate transcripts that show greater evidence for joint differential expression on both axes. Purple indicates transcripts that are concordantly regulated between the two conditions, whereas green indicates discordance. (D–F) Histograms of RSI values in (A–C). n = 6 for TMES, 2D static samples and xenografts. (G–I) Top ten concordantly (purple) and discordantly (green) regulated Reactome pathways.

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