Figure 1 | Scientific Reports

Figure 1

From: In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP)

Figure 1

Structural analysis of mAb binding to protective P. falciparum Circumsporozoite protein (CSP) epitopes. (a) Schematic representation of full-length CSP (not to scale). (b) Antibody paratope structures depicting monoclonal antibody binding to representative repeat or junctional peptides: 311 (PDB code 6AXK), 317 (6AXL)18, CIS43 bound to peptide 21 (6B5M) and peptide 29 (6B5O)12, germline 580 (6AZM) and 663 (5BK0)19, MGG4 (6BQB)21. The contact area between the peptides and the complementarity determining regions, or the buried surface area (BSA), shown under each structure were calculated using the AREAIMOL program in the CCP4 software suite43. Heavy and light chains are colored blue and light grey, respectively. Peptides are depicted in stick conformations (green carbons). Hydrogen bonds are shown as black dashes. Type I β and 310 turns are indicated by black and red circles, respectively.

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