Table 1 List of genes with significantly different expression between ADH/TO-DKH and ADH/WT hippocampi.

From: MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis

Gene Symbol#

Expression level (raw intensity)

ADH/TO-DKH vs ADH/WT

ADH/WT vs NT

ADH/TO-DKH vs NT

REF*

NT

ADH/WT

ADH/

TO-DKH

Expression change

Fold

Change

p-val

Fold

Change

p-val

Fold

Change

p-val

Ttr

984.41

14,235.25

806.34

− 13,428.91

− 17.65

8.39E-07

14.46

1.47E-06

− 1.22

4.48E-01

34, 35

Enpp2

1616.00

7703.99

1786.64

− 5917.35

− 4.31

3.10E-07

4.77

2.06E-07

1.11

5.13E-01

34, 35

Kcnj13

146.36

2745.91

76.53

− 2669.38

− 35.88

9.66E-08

18.76

4.83E-07

− 1.91

2.40E-02

35

Kl

201.89

1086.50

230.90

− 855.60

− 4.71

8.52E-08

5.38

3.59E-08

1.14

1.25E-01

33, 34, 35

Ace

93.62

630.45

125.42

− 505.03

− 5.03

6.74E-05

6.73

1.78E-05

1.34

2.20E-01

 

Sostdc1

105.15

607.70

116.59

− 491.10

− 5.21

2.74E-07

5.78

2.42E-07

1.11

8.41E-01

33, 35

Cd59a

160.67

866.81

387.18

− 479.63

− 2.24

1.60E-03

5.39

3.99E-06

2.41

3.79E-04

 

Trpm3

303.02

857.32

379.58

− 477.74

− 2.26

1.00E-04

2.83

1.71E-05

1.25

9.45E-02

33, 35

Gpx8

132.45

634.37

158.97

− 475.40

− 3.99

7.69E-07

4.79

2.12E-07

1.20

7.31E-02

 

Folr1

93.38

541.20

73.07

− 468.13

− 7.41

4.84E-09

5.80

1.30E-08

− 1.28

3.98E-02

33, 34, 35

Slc2a12

116.72

488.63

153.90

− 334.73

− 3.17

5.05E-07

4.19

1.18E-07

1.32

3.86E-02

 

Clic6

34.88

360.08

29.33

− 330.75

− 12.28

4.89E-08

10.32

8.24E-08

− 1.19

3.41E-01

33, 35

Lbp

120.68

432.24

105.19

− 327.05

− 4.11

3.22E-06

3.58

4.16E-06

− 1.15

7.58E-01

33, 34, 35

Otx2

49.47

341.26

36.31

− 304.96

− 9.40

1.07E-07

6.90

2.55E-07

− 1.36

1.64E-01

33, 35

Prlr

31.20

301.87

19.25

− 282.62

− 15.68

3.20E-07

9.67

9.55E-07

− 1.62

1.30E-01

33, 34, 35

Slc4a5

49.72

327.83

47.24

− 280.59

− 6.94

6.05E-07

6.59

1.60E-06

− 1.05

1.97E-01

34

Steap2

128.27

428.44

162.31

− 266.13

− 2.64

3.81E-05

3.34

7.02E-06

1.27

1.05E-01

 

Cab39l

217.13

508.34

264.85

− 243.49

− 1.92

2.65E-05

2.34

3.21E-06

1.22

4.08E-02

 

Rdh5

94.97

350.28

109.86

− 240.42

− 3.19

2.95E-07

3.69

1.13E-07

1.16

1.35E-01

33, 35

Tmem72

60.48

278.73

46.79

− 231.94

− 5.96

1.42E-06

4.61

4.80E-06

− 1.29

1.50E-01

 

Cldn1

80.30

315.74

87.71

− 228.03

− 3.60

5.54E-06

3.93

2.61E-06

1.09

3.74E-01

33

Slc4a2

132.24

385.55

175.84

− 209.71

− 2.19

1.00E-04

2.92

9.32E-06

1.33

3.51E-02

33

Igfbp2

122.21

341.36

137.64

− 203.72

− 2.48

3.39E-05

2.79

1.04E-05

1.13

2.47E-01

33, 34

Sulf1

79.79

268.78

76.92

− 191.86

− 3.49

8.28E-07

3.37

1.07E-06

− 1.04

7.18E-01

33, 35

Dab2

240.88

318.36

136.09

− 182.27

− 2.34

4.24E-05

1.32

1.34E-02

− 1.77

1.81E-03

 

Calml4

60.80

236.41

56.19

− 180.22

− 4.21

2.28E-05

3.89

2.42E-05

− 1.08

9.53E-01

33, 35

Col8a1

93.40

236.34

60.43

− 175.91

− 3.91

2.56E-06

2.53

1.77E-05

− 1.55

5.00E-02

33, 34, 35

C1qtnf5

102.35

260.42

87.77

− 172.65

− 2.97

9.30E-08

2.54

3.19E-07

− 1.17

6.18E-02

 

F5

32.26

203.26

32.91

− 170.35

− 6.18

5.44E-07

6.30

5.84E-07

1.02

9.16E-01

35

Pon3

64.52

224.37

67.54

− 156.83

− 3.32

3.19E-06

3.48

1.42E-06

1.05

3.12E-01

 

Pcolce2

130.51

317.52

165.02

− 152.50

− 1.92

2.00E-04

2.43

3.98E-05

1.26

1.61E-01

 

Pla2g5

68.85

208.07

66.84

− 141.24

− 3.11

7.72E-06

3.02

1.39E-05

− 1.03

5.29E-01

 

Abca4

50.42

176.06

45.88

− 130.18

− 3.84

2.48E-06

3.49

5.79E-06

− 1.10

3.20E-01

 

Drc7

60.14

191.55

63.95

− 127.61

− 3.00

8.94E-07

3.18

7.69E-07

1.06

8.30E-01

 

Car14

114.18

219.86

96.04

− 123.82

− 2.29

7.09E-05

1.93

1.67E-04

− 1.19

4.66E-01

 

Tc2n

21.09

141.21

20.55

− 120.66

− 6.87

1.90E-05

6.70

2.08E-05

− 1.03

9.28E-01

 

Aqp1

77.70

176.48

61.09

− 115.39

− 2.89

2.34E-06

2.27

1.29E-05

− 1.27

7.22E-02

33, 35

A2m

77.40

244.90

142.93

− 101.97

− 1.71

2.42E-02

3.16

3.14E-05

1.85

7.26E-04

 

Spink8

53.90

129.47

278.78

149.31

2.15

6.20E-03

2.40

4.15E-03

5.17

4.56E-05

 
  1. Genes with significantly different expression between ADH/WT and ADH/TO-DKH hippocampi are shown in order of expression change between the two groups, with comparison to data from NT (eBayes ANOVA: false discovery rate [FDR] p < 0.05, fold-change > 1.5 or < − 1.5, highest raw intensity among three groups > 100).
  2. *Altered expression of the corresponding gene was reported in hippocampus prepared from different mouse lines carrying neuron-specific enolase/human Tau23 transgene 33, APPswe transgene 34 or neuronal conditional deletion of App and Aplp2 35.
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