Table 1 Clinical and histological patients feature.

From: Hepatic lymphocytes involved in the pathogenesis of pediatric and adult non-alcoholic fatty liver disease

Factor

Patients

Pediatric

Adult

Age (years) median (min.–max.)

11.5 (4–17)

50 (28–72)

Gender [male, %(n/total)]

65.38 (17/26)

52.94 (18/34)

Clinical and serological characteristics

BMI

 Overweighed %(n/total)

11.53 (3/26)

29.41 (24/34)

 Obese %(n/total)

76.96(20/26)

70.59 (10/34)

Transaminases

 ALT (IU/l) median (min.–max.)

31.5 (16–216)

80 (31–279)

 Elevated %(n/total)

50 (13/26)

94.12 (32/34)

 AST (IU/l) median (min.–max.)

40.5 (15–213)

48 (22–208)

 Elevated %(n/total)

42.31 (11/26)

61.76 (21/34)

 AST/ALT ratio median (min.–max.)

0.75(0.385–1.409)

0.63 (0.32–1.07)

Lipid profile median (min.–max.)

 Cholesterol mg/dl

154.5 (88–224)

207 (126–327)

 Triglycerides mg/dl

100 (28–212)

166 (60–465)

Histological characteristics*

Steatosis%(n/total)

  

 0

–

–

 1

15.38 (4/26)

17.65 (6/34)

 2

19.23 (5/26)

26.47 (9/34)

 3

65.39 (17/26)

55.88 (19/34)

Lobular inflammation%(n/total)

  

 0

3.85 (1/26)

17.65 (6/34)

 1

80.77 (21/26)

64.70 (22/34)

 2

7.69 (2/26)

17.65 (6/34)

 3

7.69 (2/26)

–

Ballooning %(n/total)

  

 0

–

11.76 (4/34)

 1

69.23 (18/26)

64.71 (22/34)

 2

30.77 (8/26)

23.53 (8/34)

NAFLD activity score %(n/total)

  

  ≤ 2

–

8.82 (3/34)

 3–4

23.08 (6/26)

38.24 (13/34)

  ≥ 5

76.92 (20/26)

52.94 (18/34)

Fibrosis %(n/total)

  

 0

–

67.65 (23/34)

 1

15.38 (4/26)

14.71 (5/34)

 2

23.08 (6/26)

11.76 (4/34)

 3

57.69 (15/26)

5.88 (2/34)

 4

3.85 (1/26)

–

 n

26

34

  1. BMI: Body Mass Index (kg/m2), in pediatric patients the values defined by the Argentine Society of Pediatrics were used to determine overweight and obesity (https://www.sap.org.ar/uploads/consensos/obesidad-gu-iacuteas-para-su-abordaje-cl-iacutenico-2015.pdf). In the case of adult patients: normal weight (< 25.0 kg/m2), overweight (25.0–29.9 kg/m2) and obesity (≥ 30 kg/m2). ALT alanine aminotransferase; AST aspartate aminotransferase. Normal ALT and AST levels for pediatric patients were ≤ 32 and ≤ 48 IU/L, respectively when testing was done at 37 °C. Normal ALT and AST levels for adult patients were ≤ 40 and ≤ 42 IU/L, respectively when testing was done at 37 °C. The normal ranges for cholesterol and triglyceride were 120–219 mg/dl and 31–119 mg/dl, respectively. *Steatosis Grade: score 0 (< 5%cells), 1 (5–33%), 2 (33–66%) and 3 (> 66%); lobular inflammation: score 0 (0 foci), 1 (< 2 foci), 2 (2–4 foci) and 3 (> 4 foci); ballooning grade: score 0 (none), 1 (few ballooning cells) and 2 (many cells/prominent cells); fibrosis stage: score 1 (a, b = mild (1a)/ moderate (1b) zone 3 perisinusoidal fibrosis; 1c = only portal fibrosis); 2 (zone 3 and portal/ periportal fibrosis), 3 (bridging fibrosis) and 4 (cirrhosis).
Back to article page