Table 2 Annotation about cell clusters in CRC datasets.

Cluster	Cell number	Function annotation	Type
CD8_C01.LEF1	164	Naïve T cell	CD8⁺ T cell
CD8_C02.GPR183	155	Central memory T cell	CD8⁺ T cell
CD8_C03.CX3CR1	773	Effector T cell	CD8⁺ T cell
CD8_C04.GZMK	363	Effector memory T cell	CD8⁺ T cell
CD8_C05.CD6	431	Resident memory T cell	CD8⁺ T cell
CD8_C06.CD160	363	Intraepithelial lymphocytes	CD8⁺ T cell
CD8_C07.LAYN	831	Exhausted T cell	CD8⁺ T cell
CD8_C08.SLC4A10	71	MAIT	CD8⁺ T cell
CD4_C01.CCR7	472	Naïve T cell	CD4⁺ T cell
CD4_C02.ANXA1	509	Central memory T cell	CD4⁺ T cell
CD4_C03.GNLY	170	Effector T cell	CD4⁺ T cell
CD4_C04.TCF7	331	Central memory T cell	CD4⁺ T cell
CD4_C05.CXCR6	639	Resident memory T cell	CD4⁺ T cell
CD4_C06.CXCR5	216	T follicular helper cell	CD4⁺ T cell
CD4_C07.GZMK	204	TH-1 like cell	CD4⁺ T cell
CD4_C08.IL23R	229	TH-17 like cell	CD4⁺ T cell
CD4_C09.CXCL13	272	Exhausted T cell	CD4⁺ T cell
CD4_C10.FOXP3	365	Peripheral Treg	CD4⁺ T cell
CD4_C11.IL10	176	Follicular regulatory T cells	CD4⁺ T cell
CD4_C12.CTLA4	1319	Tumor Treg	CD4⁺ T cell

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