Figure 2
From: Elevated levels of mitochondrial CoQ10 induce ROS-mediated apoptosis in pancreatic cancer
BPM31510 decreases Q-pool linked Complex II and mitochondrial glycerol-3-phosphate dependent respiration, resulting in shifts in respiratory dependency of specific mitochondrial complexes. (a) State 3 respiration on pyruvate/malate + succinate + glycerol-3-phosphate in MIA PaCa-2 and PANC1 cells after BPM31510 treatment. (b) Effects of BPM31510 on electron transport chain complex (substrate-specific) respiration in MIA PaCa-2 and PANC1 cells. The data represent the means + SEM of three independent experiments. (c) BPM31510 shifts respiratory dependency in MIA PaCa-2 and PANC1 cells. Complex-specific respiration was assessed as described in the Methods section. The data report the percentage of total respiration. The data represent the means + SEM of three independent experiments. The data were analysed by Student’s t-tests; ***p < 0.001 compared to untreated cells.
