Table 1 Selection criteria for clustering of diseases.
From: Characterisation, identification, clustering, and classification of disease
Clinical inclusion criteria | Eligible hospital episodes | |
|---|---|---|
Prior disease | Diseases were the first primary hospital diagnosis in each ICD-10 chapter | 425,383 male |
502,771 female | ||
+ Clinical considerations | Clinically distinct, age-related disease, or R-coded diseases of unknown aetiology | 400,006 male |
468,398 female | ||
Statistical inclusion criteria | Eligible diseases | |
Successful fit | At least 50 cases, and a covariance matrix with no unusually large or small eigen values that exceed the mean by 2.5 standard deviations when outliers were included | 343 male |
346 female | ||
+ Statistically significant | Statistically significant risk factors at the 0.05 level,after a multiple-testing Bonferroni adjusted multivariate \(\chi ^2\) test | 150 male |
140 female | ||
+ Proportional hazards | Test of proportional hazards assumption—no statistically significant deviation at the 0.05 level, after a multiple-testing FDR adjustment | 138 male |
127 female | ||
+ Unisex | The set must include the same disease in both men and women | 86 male and female |
