Figure 1
From: EMeth: An EM algorithm for cell type decomposition based on DNA methylation data
Evaluation of different methods using simulated data. The upper panel shows the RMSE in 25 repetitions of all five methods in one group of simulation parameters (\(\sigma _c^2 = 0.004\), \(\lambda = 10\)). We compare the RMSE for each cell type separately. Under this setting, EMeth dominates the result in all cell types. Two panels in the bottom panel display estimates of CD4T proportions by EMeth and SVRs for 100 samples. In this case, both methods have reasonable performances, though SVR has a systematic bias. These plots were generated using ggplot2 version 3.3.124.
