Figure 1
Capsid structures of EV-A71, CV-A16 and CV-A10. (A–C) Radius-colored surface representations of EV-A71 (A), CV-A16 (B) and CV-A10 (C). Capsids are colored according to their radius from blue to red as shown in the color bar. The multiple chains consisting of four units labeled as chain 1–4 are indicated by black triangles. Fivefold, threefold and twofold vertexes are marked as pentagons, triangles and ovals, respectively. (D–F) Zoom-in views of multiple chains and capsid characteristics of EV-A71 (D), CV-A16 (E) and CV-A10 (F). The color scheme is as described in the legend to (A–C). The central chain (chain 1) is outlined by a black triangle. (G–I) The predicted conformational epitopes on the chain 1 of EV-A71 (G), CV-A16 (H) and CV-A10 (I). The prediction results of conformational epitopes for CV-A10 are obtained from our previous work with permission from the journal44. Structural proteins VP1-3 are shown as surface representations in light pink, light blue and light orange, respectively. The chain 1 is outlined as the (D–F). The conformational epitopes clustered into three sites are highlighted in red (site 1), green (site 2) and blue (site 3), respectively.
