Figure 4

Pathways involved in mitochondrial dysfunction significantly altered in CTEPH patients ((last version IPA, QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuitypathway-analysis), in red the increased genes, in green those decreased. The color intensity is positive related to the up- or down-gene’s regulation; orange line leads to activation, yellow lines for findings inconsistent with state of downstream molecule; grey line for effect not predicted.