Figure 5

Adult rat cortex demonstrates long-term oxidative damage following P7 sevoflurane exposure. Lipid peroxidation adducts (4-HNE) were increased in sevoflurane exposed rat brains (a), indicating persistent oxidative stress. However, SOD2 has not increased, indicating the lack of a compensatory mitochondrial anti-oxidant response (b,c). Values represent means ± SEM, with 6 animals in each group. Statistical significance between groups indicated with (*) for p-value < 0.05. All samples derived from same experiment and gels/blots processed in parallel.