Figure 8 | Scientific Reports

Figure 8

From: Singular and short-term anesthesia exposure in the developing brain induces persistent neuronal changes consistent with chronic neurodegenerative disease

Figure 8

Early-life sevoflurane exposure can induce perpetuating neuronal dysfunction in the adult brain. Our findings indicate that anesthesia exposure in the developing brain adversely alters cellular energetic function through changes to mitochondrial morphology and function, resulting in a lasting adverse shift in mitochondrial quality control and regeneration/biogenesis pathways. This mechanism allows poorly functional organelles to persist, inducing proteotoxicity, oxidative stress, and neuroinflammation, creating a cell non-autonomous propagation of the phenotype, potentially through Cdk1.Image created using BioRender.com.

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