Figure 6

Our drug response prediction workflow discovers a panel of genes and related drugs/drug-combinations for personalized therapy in bladder cancer. The figure illustrates the final selection of drug-gene interactions (including combination treatments). “Sensitivity” and “resistance” refer to predicted sensitivity and resistance when the associated gene contains a respective variant. “Sensitivity unspecific” refers to genes where sensitivity to a particular drug could not be assigned to a particular variant but multiple variants would lead to the prediction. In “variant dependent” predictions, different variants within one gene can cause a divergent direction of the response prediction (sensitivity/resistance). (R Core Team (2019). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/)⁵⁷.