Figure 6

Evaluation of functional roles of the differentially expressed genes (P < 0.01; fold change greater or equal to 1.5 or less or equal to − 1.5), a KEGG pathway analysis was performed^25,26. Statistically significant alterations are illustrated as Voronoi tessellations, created using Voronto mapper web service²⁷. Voronoi maps integrate expression data and biological ontologies, allowing the evaluation the whole ontology and detection of changes on expression patterns inside the ontology. Each section represents a hierarchy level of ontology. The size of each cell represents the number of annotated genes identified for each ontology term. The final visualization represents three ontology levels for each dataset. Each term is represented by a polygon colored with its expression. Terms with a common ancestor are represented by adjacent polygon and surrounded by a wider line. Colors from white to red indicate overexpression; colors from white to blue indicate underexpression.