Figure 7

Heat map of B. cenocepacia adhesion and invasion related genes expression during adhesion to 16HBE14o- GPMVs. Colors from white to pink indicate upregulated cellular genes; colors from white to blue indicate downregulated cellular genes. Heat maps were created using Heatmapper online platform (http://www.heatmapper.ca)70. Several genes that promote B. cenocepacia K56-2 interaction with the host cell, including genes that encode for adhesins, outer membrane proteins, lipoproteins and proteins involved in pilus and flagella assembly were differentially regulated upon GPMV-adhesion.