Figure 5
From: Metabolic engineering of probiotic Escherichia coli for cytolytic therapy of tumors
Tumor regression by EcNe/HlyE. (a) The change in the body weight of mice receiving intraperitoneal injection of bacteria. (b) Therapeutic effect of EcNe/HlyE on mice (n = 5) bearing SW620 or HT29 tumor cells. Tumor volumes (mm3) were estimated using external calipers, and values were expressed as means ± standard deviations (SD). The statistical significance was analyzed by Student's t-test (*p < 0.05; **p < 0.01; and ***p < 0.001 vs. the PBS group). (c) Distribution of bacteria in vivo.
